CXCL8/IL-8 Antibody (N11) Summary
| Immunogen |
The immunogen for this antibody is IL8.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
IL8
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Application Notes |
This N11 antibody has been tested by immunoblot of peripheral blood mononuclear cells stimulated with LPS for 4 hours. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. ELISA was reported in scientific literature.
|
|
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Aqueous, may contain carrier protein/stabilizer.
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for CXCL8/IL-8 Antibody (N11)
- 3-10C
- AMCF-I
- C-X-C motif chemokine 8
- CXCL8
- CXCL8SCYB8
- Emoctakin
- GCP1
- GCP-1TSG-1
- IL8
- IL-8
- interleukin 8
- K60
- LAI
- LECT
- MDNCF
- MDNCFb-ENAP
- member 8
- MONAPGCP1
- NAP1
- NAP-1NAP1
- NCF
- Neutrophil-activating protein 1
- Protein 3-10C
- T cell chemotactic factor
- T-cell chemotactic factor
- TCF
- TSG1
Background
The monoclonal antibody N11 reacts specifically with the 77 amino acid form of IL-8 (IL-877, IL-8(1-77), CXCL877) and does not react with the more common 72 amino acid form. Frequently referred to as “endothelial” IL-8, the 77 amino acid form is secreted in cultured leukocytes. The 72 amino acid form is the result of efficient cleavage of an N-terminal pentamer from IL-877 after secretion. IL-8 is a C-X-C chemokine with potency in neutrophil chemotaxis and activation. IL-877 has decreased chemotactic activity when compared to IL-872, but has other specific pro-apoptotic and tumor cell chemotactic activities. IL-877 has recently been shown to be the major isoform present in premature neonates due to deficiency in serum protease activity that is not seen in term neonates.