Tenascin X Antibody (BC-24) Summary
| Immunogen |
Full length purified human native protein to Tenascin.
|
| Epitope |
BC-24 recognizes an epitope located within the N-terminal EGF-like sequence of the human tenascin molecule.
|
| Localization |
Neo-expression or increased expression of TN has been found in the stroma of various tumors and during normal tissue repair. Intracytoplasmic TN immunoreactivity has been detected in malignant melanomas and in lung carcinomas.
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| Specificity |
Recognizes all human tenascin isoforms.
|
| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
TNXB
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
15mM Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for Tenascin X Antibody (BC-24)
- Hexabrachion-like protein
- HXBL
- Tenascin X
- tenascin XB
- tenascin XB2
- tenascin-X
- TNX
- TNXB
- TNXB1growth-inhibiting protein 45
- TNXB2tenascin XB1
- TNXBS
- TNXBSTNXTENX
- XB
- XBS
- XB-S
- XBTN-X
Background
Tenascin (TN)1,2 is a high molecular weight, multifunctional, extracellular matrix glycoprotein, expressed in association with mesenchymal-epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors. It has been described under a variety of names: cytotactin, hexabrachion protein, J1-200/220, myotendinous antigen (MI), neuronectin (NEC1) and glioma mesenchymal extracellular matrix (GMEM). The TN molecule is a disulfide-linked hexamer; depending on species, the molecular weights of the subunits range from 190 to 320 kD. In the mouse, two major subunits of tenascin with an apparent MW of 210 and 260 kD have been described, with the shorter polypeptide predominating during early developmental stages and the larger polypeptide appearing later in the embryonic gut and in the adult intestine.3 Human TN has 3 subunits of 190, 200 and 220 kD. It is primarily made up of 14.5 epidermal growth-factor-like repeats, 15 units similar to the fibronectin type-III-homology repeat and, at the C-terminus, has a sequence with homology to the globular domain of the