Product: 3,6-Dicaffeoylquinic acid
Bcl-10 Antibody (151) Summary
| Immunogen |
Recombinant full length protein (Human).
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| Epitope |
The epitope recognized by the antibody resides within amino acids 122-168 of human Bcl 10 molecule.
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| Localization |
Cytoplasmic. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells.
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| Specificity |
Bcl 10 (151)
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
BCL10
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IHC-P: Perform heat mediated antigen retrieval before commencing with IHC staining protocol. WB: Detects bands of approximately 20, 32 and 37 kDa.
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| Positive Control |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
10mM PBS (pH 7.4)
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| Preservative |
15mM Sodium Azide
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| Concentration |
2.0 mg/ml
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| Purity |
Protein A purified
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Alternate Names for Bcl-10 Antibody (151)
- B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10
- Bcl10
- Bcl-10
- CARD-containing apoptotic signaling protein
- CARD-containing molecule enhancing NF-kappa-B
- CARD-containing proapoptotic protein
- CARD-like apoptotic protein
- CARMEN
- caspase-recruiting domain-containing protein
- cCARMEN
- c-E10
- c-E10bcl-10
- CED-3/ICH-1 prodomain homologous E10-like regulator
- Cellular homolog of vCARMEN
- cellular-E10
- CIPER
- CLAP
- hCLAP
- Mammalian CARD-containing adapter molecule E10
- mE10
- mE10CARD containing molecule enhancing NF-kB
Background
Bcl 10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl 10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl 10 cellular overexpression induces JNK, p38, and NF-kappaB activation. Deregulation of Bcl 10 expression was also demonstrated to be involved in cellular oncogenesis.