Sirtuin 1/SIRT1 Antibody Summary
| Immunogen |
Antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SIRT1. The immunogen is located within the first 50 amino acids of SIRT1.
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| Clonality |
Polyclonal
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| Host |
Chicken
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| Gene |
SIRT1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Sirtuin 1/SIRT1 Antibody
- EC 3.5.1
- S. cerevisiae, homolog) 1
- SIR2alpha
- SIR2L1
- SIR2-like protein 1
- SIRT1
- Sirtuin 1
Background
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue.