Product: Piboserod (hydrochloride)
PDP1/PPAPDC2 Antibody Summary
| Immunogen |
Antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus human PPAPDC2. The immunogen is located within amino acids 170 – 220 of PPAPDC2.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PPAPDC2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PDP1/PPAPDC2 Antibody
- bA6J24.6
- EC 3.1.3
- EC 3.1.3.-
- FLJ46512
- FLJ90191
- MGC15483
- PDP1
- phosphatidic acid phosphatase type 2 domain containing 2
- Phosphatidic acid phosphatase type 2 domain-containing protein 2
- polyisoprenoid diphosphate phosphatase type 1
- PPAP2 domain-containing protein 2
- presqualene diphosphate phosphatase
- PSDP
Background
PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.