RSK1 Antibody Summary
| Immunogen |
Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human RPS6K1. The immunogen is located within amino acids 600 – 650 of RPS6K1.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
RPS6KA1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
RPS6K1antibody can be used for the detection of RPS6K1 by Western blot at 5 – 10 mg/ml.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for RSK1 Antibody
- 90kD, polypeptide 1)
- EC 2.7.11
- EC 2.7.11.1,90 kDa ribosomal protein S6 kinase 1
- HU-1
- MAP kinase-activated protein kinase 1a
- MAPK-activated protein kinase 1a
- MAPKAP kinase 1a
- MAPKAPK-1a
- MAPKAPL1A
- p90RSK1
- p90S6K
- ribosomal protein S6 kinase alpha 1
- ribosomal protein S6 kinase alpha-1
- ribosomal protein S6 kinase, 90kD, polypeptide 1
- ribosomal protein S6 kinase, 90kDa, polypeptide 1
- Ribosomal S6 kinase 1
- RPS6KA1
- RSK
- RSK1
- RSK-1
- RSK1p90-RSK 1
- S6K-alpha 1
- S6K-alpha-1
Background
Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and GbetaL to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth. RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice.