ATOH8 Antibody Summary
| Immunogen |
Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATOH8. The immunogen is located within the last 50 amino acids of ATOH8.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ATOH8
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Theoretical MW |
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for ATOH8 Antibody
- ATH6
- atonal homolog 6
- atonal homolog 8 (Drosophila)
- basic helix-loop-helix transcription factor 6
- BHLHA21
- bHLHa21basic helix loop helix transcription factor 6
- Class A basic helix-loop-helix protein 21
- FLJ14708
- FLJ38730
- HATH6
- Helix-loop-helix protein hATH-6
- protein atonal homolog 8
Background
Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43–57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.