Cdc27 Antibody Summary
| Immunogen |
Antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human APC3. The immunogen is located within the last 50 amino acids of APC3.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CDC27
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Cdc27 Antibody
- ANAPC3CDC27 homolog
- anaphase promoting complex subunit 3
- Anaphase-promoting complex subunit 3
- anaphase-promoting complex, protein 3
- APC 3
- APC3cell division cycle 27
- CDC27Hs
- cell division cycle 27 homolog (S. cerevisiae)
- cell division cycle protein 27 homolog
- D0S1430E
- D17S978E
- HNUC
- H-NUC
- nuc2 homolog
- NUC2
Background
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC3, also known as CDC27, a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. APC3 contains a tetratricopeptide repeat (TPR) region and interacts with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1.