Product: Ingenol-5,20-acetonide-4-O-angelate
2B4/CD244/SLAMF4 Antibody Summary
| Immunogen |
Antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SLAMF4. The immunogen is located within the last 50 amino acids of SLAMF4.
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| Specificity |
At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CD244
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for 2B4/CD244/SLAMF4 Antibody
- 2B4
- CD244 antigen
- CD244 molecule, natural killer cell receptor 2B4
- CD244
- h2B4
- NAIL
- NAILNK cell activation-inducing ligand
- natural killer cell receptor 2B4
- NKR2B4
- NKR2B4NK cell type I receptor protein 2B4,2B4CD244 natural killer cell receptor 2B4
- Nmrk
- SLAMF4
- SLAMF4NK cell activation inducing ligand NAIL
Background
The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.