ATG16L1 Antibody Summary
| Immunogen |
Antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human ATG16. The immunogen is located within amino acids 40 – 90 of ATG16.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ATG16L1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
||
| Theoretical MW |
68 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
||
| Control Peptide |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ATG16L1 Antibody
- APG16 autophagy 16-like (S. cerevisiae)
- APG16L beta
- APG16LFLJ10828
- APG16-like 1
- ATG16 autophagy related 16-like (S. cerevisiae)
- ATG16 autophagy related 16-like 1 (S. cerevisiae)
- ATG16A
- ATG16L
- autophagy-related protein 16-1
- FLJ00045
- FLJ10035
- FLJ22677
- IBD10
- WD repeat domain 30
- WDR30
Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjugate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been suggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.