Product: Ingenol-3,4,5,21-diacetonide
CLIP170 Antibody Summary
| Immunogen |
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170. The immunogen is located within amino acids 1340 – 1390 of CLIP170.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CLIP1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CLIP170 Antibody
- CAP-GLY domain containing linker protein 1
- CLIP
- CLIP170
- CLIP-170Reed-Sternberg intermediate filament-associated protein
- CYLN1MGC131604
- cytoplasmic linker 1
- Cytoplasmic linker protein 1
- Cytoplasmic linker protein 170 alpha-2
- Reed-Steinberg cell-expressed intermediate filament-associated protein
- restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
- Restin
- RSNCAP-Gly domain-containing linker protein 1
Background
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkins disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.