Neisseria Meningitidis Antibody Summary
| Immunogen |
Whole cell preparation of N. meningitidis types A, B and C
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| Specificity |
NB100-64560 reacts with Neisseria meningitidis serogroups A, B and C and is thought to recognize all antigens. Other serogroups have not been tested. N. meningitidis is a gram-negative bacteria that is the causative agent of meningitis. There are 13 known significant serogroups that are classified according to the structure of their polysaccharide capsule. Serogroups, A, B, C, D, X, Y, Z, 29E and W135 are responsible for virtually all cases of the human disease. The carbohydrate component of the capsular membrane induces a T cell independent immune response, so neither long term immunity by memory cell formation nor antibody affinity maturation is observed. Rather than being engulfed and processed by an antigen presenting cell, the carbohydrate capsule interacts directly with B cells. This interaction causes production of serogroup specific antibodies, primarily IgM. IgG is also produced with an IgG1 response predominating in children and an IgG2 response predominating in adults.
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| Clonality |
Polyclonal
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| Host |
Rabbit
|
| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
4 mg/ml
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| Purity |
IgG purified
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Alternate Names for Neisseria Meningitidis Antibody
- N meningitidis
- N.meningitidis
Background
Neisseria meningitidis is a causative agent of bacterial meningitis and resides within the nasopharyngeal tract of humans. Strains of N. meningitidis are characterized by the polysaccharide expressed on its capsule. Serogroups A, B and C cause 90% of meningococcal meningitis cases. The carbohydrate component of the capsular membrane induces a T independent immune response so neither long term immunity by memory cell formation nor antibody affinity maturation is observed. Rather than being engulfed and processed by an antigen presenting cell,the carbohydrate capsule interacts directly with B cells. This interaction causes production of serogroup specific antibodies, primarily IgM. IgG is also produced with an IgG1 response predominating in children and an IgG2 response predominating in adults. The immune systems of infants are not sufficiently developed to achieve an immune response to the polysaccharide membrane which accounts for the prevalence of meningitis in this age group. Persons most susceptible to the infection are often immunocompromised, immunosuppressed or suffering from head trauma. Others acquire infection through close contact with a primary carrier.