Product: Pantoprazole (sodium hydrate)
Integrin alpha 4/CD49d Antibody (9C10 (MFR.4.B)) Summary
| Immunogen |
Mouse LyD9 haematopoietic progenitor cells
|
| Localization |
Type I membrane protein
|
| Specificity |
NB100-64905 recognizes murine alpha 4 integrin (CD49d), a 150kD glycoprotein that can associate with either beta 1 integrin (CD29) or beta 7 integrin to form heterodimers CD49d/CD29 (VLA-4) and alpha4/beta7 (LPAM-1) respectively. CD49d is expressed on most lymphocytes, granulocytes, monocytes and thymocytes. The primary ligands for CD49d are CD106 (VCAM-1), fibronectin and MAdCAM-1. Clone 9C10 (MFR4.B) is reported to significantly inhibit binding of CD49d to CD106 but only when used in combination with clone R1-2 (1) Removal of sodium azide is recommended prior to use in functional assays.
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
ITGA4
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Integrin alpha 4/CD49d Antibody (9C10 (MFR.4.B))
- 269C wild type
- CD49 antigen-like family member D
- CD49d antigen
- CD49d
- CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor
- IA4
- Integrin alpha 4
- integrin alpha-4 subunit
- integrin alpha-4
- Integrin alpha-IV
- integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
- ITGA4
- MGC90518
- very late activation protein 4 receptor, alpha 4 subunit
- VLA-4 subunit alpha
- VLA-4
Background
Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohns disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.