CD40/TNFRSF5 Antibody (39530) Summary
| Immunogen |
Extracellular Domain of Mouse CD40 and the Fc portion of Human IgG1
|
| Localization |
Cell Membrane and Secreted
|
| Specificity |
Specificity was checked by ELISA and flow cytometry using BHK cells transfected with mouse CD40. It does not react with normal mouse Ig or with human IgG1 and will stain most mature mouse B cells. It does not cross react with mouse T cells. Clone 3/23 is a powerful activator of normal B cells especially in the presence of IL-4.
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
CD40
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for CD40/TNFRSF5 Antibody (39530)
- B cell surface antigen CD40
- B-cell surface antigen CD40
- Bp50B cell-associated molecule
- CD40 antigen
- CD40 molecule, TNF receptor superfamily member 5
- CD40 type II isoform
- CD40
- CD40L receptor
- CDw40
- MGC9013
- nerve growth factor receptor-related B-lymphocyte activation molecule
- p50
- TNFRSF5
- TNFRSF5CD40 antigen (TNF receptor superfamily member 5)
- tumor necrosis factor receptor superfamily member 5
- tumor necrosis factor receptor superfamily, member 5
Background
CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.