Feline Leukaemia Virus gp70 Antibody (C11D8) Summary
| Immunogen |
Made to Viral FELINE LEUKAEMIA VIRUS gp70
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| Specificity |
NB100-65565 recognizes the gp85/gp70 envelope glycoprotein of feline leukaemia virus. The antibody specifically recognizes the epitope defined by amino acids 214-218 of the gp70 sequence (aa MGPNL). Some weak cross-reactivity with the sequence MGPLL found in the FeLV p15e membrane protein may also occur. This antibody effectively neutralises all three FeLV subgroups (A,B and C).
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| Isotype |
IgG2b
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Removal of sodium azide is recommended prior to use in functional assays.
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2)
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| Preservative |
0.05% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Protein A purified
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Alternate Names for Feline Leukaemia Virus gp70 Antibody (C11D8)
- Env polyprotein
- Feline Leukemia Virus glycoprotein 70
- Glycoprotein gp70 [Precursor]
- GP70 envelope protein
- gp70 protein (SU)
- p15E protein (TM)
- p15E protein
Background
FeLV is a retrovirus (family Oncovirinae) that can cause severe immunosuppression, severe non regenerative anemia, and a variety of neoplasms. The 3 main subtypes (FeLVA, FeLVB and FeLVC) may act independently or together to cause a variety of diseases. The major envelope glycoprotein (gp70) is used to bind to target cells and varies with the FeLV subtype.