Progesterone Antibody Summary
| Immunogen |
Progesterone conjugated to bovine serum albumin
|
| Localization |
Secreted
|
| Specificity |
NB100-62847 is specific for progesterone, a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Cross reactivity: 100% Progesterone 4% 11-deoxycoritcosterone 4% Corticosterone 3% 11 Hydroxyprogesterone 2.5% 20 Dihydroprogesterone 1.5% 17A Hydroxyprogesterone Less than 0.005% pregnanetriol, dihydrotestosterone, androstanedione, 11-deoxycortisol, 21 deoxycortisol, testostserone, 17b oestradiol, 17a oestradiol, dehydroepiandrosterone, androsterone, pregnanediol, pregnenolone, oestrone, oestriol, 16-Epi oestriol, and 6 keto oestradiol. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta in order to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Progesterone is available as a pharmaceutical that can be used to treat menstrual disorders and for the prevention of miscarriage. This product also exhibits negligible cross reactivity with a variety of related steroids and derivatives.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Broad
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
5.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Progesterone Antibody
- Pregn 4 ene 3 20 dione
- Progesterone
Background
Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Progesterone receptor, a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. Although PRA and PRB share several structural domains, they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap. It is composed of three domains: a modulating N terminal domain, a DNA binding domain and a C terminal steroid binding domain.