CD8 alpha Antibody (144B) Summary
| Immunogen |
Synthetic peptide corresponding to 13 C-terminal amino acids of the cytoplasmic domain of human CD8 molecule.
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| Localization |
Cell Membrane
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
CD8A
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| Purity |
Tissue culture supernatant
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
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| Theoretical MW |
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Positive Control |
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Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
No buffer
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| Preservative |
Sodium Azide
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| Purity |
Tissue culture supernatant
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Alternate Names for CD8 alpha Antibody (144B)
- CD8 antigen, alpha polypeptide (p32)
- CD8
- CD8a antigen
- CD8a molecule
- Leu2 T-lymphocyte antigen
- Leu2
- MAL
- OKT8 T-cell antigen
- p32
- RPA-T8 antibody flow
- RPA-T8 Antibody
- RPA-T8 CD8
- RPA-T8 Clone
- RPA-T8 Flow
- T cell co-receptor
- T8 T-cell antigen
- T-cell antigen Leu2
- T-cell surface glycoprotein CD8 alpha chain
- T-lymphocyte differentiation antigen T8/Leu-2
Background
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.