HBcAg Antibody Summary
| Immunogen |
HBcAg purified from the lysate of E.coli infected with the viral core DNA.
|
| Localization |
Nuclear
|
| Specificity |
This antigen stains the nuclei of liver cells of Hepatitis type B virus infected patients.
However, occasional staining may also be seen in the perinuclear cytoplasm of the infected cells. |
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
HBVgp4
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required. We suggest an incubation period of 30-60 minutes at room temperature.
|
Reactivity Notes
This antigen reacts in the nuclei of the liver cells of the Hepatitis type B virus infected patients
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS
|
| Preservative |
Sodium Azide
|
| Purity |
IgG purified
|
Notes
This product has a prediluted size available. If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution). Use recommended dilution for the concentrated vials only.
Alternate Names for HBcAg Antibody
- c
- Core antigen
- HBc
- HBcAg
- Hepatitis B Virus core antigen
Background
Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner “core particle” enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection. This antibody stains predominantly the nuclei of liver cells. Occasionally variable staining may also be seen in the perinuclear cytoplasm.