hnRNP U Antibody Summary
| Immunogen |
Synthetic peptides corresponding to HNRNPU(heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)) The peptide sequence was selected from the N terminal of HNRNPU.Peptide sequence NGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEE
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
HNRNPU
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This is a rabbit polyclonal antibody against HNRNPU and was validated on Western blot.
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS & 2% Sucrose.
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Notes
The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
Alternate Names for hnRNP U Antibody
- heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- heterogeneous nuclear ribonucleoprotein U
- hnRNP U
- HNRPU
- p120 nuclear protein
- p120
- pp120
- SAFA
- SAF-AhnRNPU
- Scaffold attachment factor A
- U21.1
Background
HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. HNRNPU contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. But this cleavage does not affect the function of the encoded protein in RNA metabolism. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.