Product: Hydrocortisone (acetate)
Presenilin-1 Antibody (34-4C3) Summary
| Immunogen |
The I3 loop of the M2 receptor fusion protein (residues 225-359) was used as an immunogen
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PSEN1
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Immunohistochemistry: It works well in fixed tissue, but not paraffin-embedded tissue. Not recommended for use in Western Blot
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| Theoretical MW |
52.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for Presenilin-1 Antibody (34-4C3)
- AD3EC 3.4.23.-
- Alzheimer disease 3
- EC 3.4.23
- FAD
- presenilin 1
- Presenilin1
- Presenilin-1
- Protein S182
- PS-1
- PS1presenilin-1
- PSEN1
- PSNL1
- S182
Background
The PSEN1 gene encodes a protein called Presenilin 1. This protein is involved in the development of the central nervous system and neuron survival Mutations in Presenilin 1 gene are the most common cause of early-onset Alzheimer disease and account for almost 70 percent of cases. These mutations result in increased production of the longer form of amyloid beta since Presenilins are thought to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.