Triadin Antibody (GE 4.90) Summary
| Immunogen |
Purified rabbit fast skeletal muscle triadin.
|
| Specificity |
Triadin (GE 4.90)
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| Isotype |
IgG
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
TRDN
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites with PBS
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for Triadin Antibody (GE 4.90)
- dJ166D18.1 (triadin)
- TDN
- triadin
- TRISK
Background
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPRs) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyRs), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, Triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPRs and RyRs. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.