Product: Carbamoylcholine (chloride)
CASK Antibody Summary
| Immunogen |
Synthetic Peptide: C(578) E R D S P S T S R Q S P A N(592)
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| Epitope |
The epitope lies between amino acid residues 578-592 from human CASK.
|
| Localization |
Cytoplasmic (Potential).
|
| Specificity |
By Western blot, this detects a 112 kDa protein representing CASK from AtT20 cell lysate. Immunohistochemical staining of CASK in mouse brain with this results in staining of the choroid plexus.
|
| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CASK
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS, 1 mg/ml BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
|
Alternate Names for CASK Antibody
- calcium/calmodulin-dependent serine protein kinase (MAGUK family)
- calcium/calmodulin-dependent serine protein kinase membrane-associatedguanylate kinase
- Calcium/calmodulin-dependent serine protein kinase
- CAMGUK
- CMG
- EC 2.7.11
- EC 2.7.11.1
- FGS4CAGH39
- FLJ22219
- hCASK
- LIN2FLJ31914
- MICPCH
- peripheral plasma membrane protein CASK
- Protein lin-2 homolog
- TNRC8
- trinucleotide repeat containing 8
Background
Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112-kDa member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements.