FOXO3 Antibody Summary
| Immunogen |
Synthetic peptide corresponding to residues L N(654) V G N F T G A K Q A S S Q S W V(670) of human FOXO3.
|
| Specificity |
FOXO3
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
FOXO3
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
WB: Analysis of rat heart and lung, Detects an approx. 71 kDa protein representing FoxO3.
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS containing 1 mg/ml BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for FOXO3 Antibody
- AF6q21 protein
- AF6q21
- DKFZp781A0677
- FKHRL1
- FKHRL1MGC31925
- FKHRL1P2
- forkhead box O3
- forkhead box protein O3
- forkhead homolog (rhabdomyosarcoma) like 1
- Forkhead in rhabdomyosarcoma-like 1
- forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
- FOXO2
- FoxO3
- FOXO3A
- FOXO3Aforkhead box O3A
- MGC12739
Background
FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation. FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors. It recognizes and binds to the DNA sequence 5-[AG]TAAA[TC]A-3. FOXO3a has been shown to induce cell growth arrest to effect tumor suppression and FOXO3A genotype is strongly associated with human longevity.