FKBP15 Antibody Summary
| Immunogen |
A synthetic peptide mapping to a region between residues 50 and 100 of human FK506-binding protein 135 using the numbering given in TrEMBL entry Q9Y4D0 (GeneID 23307).
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| Predicted Species |
Equine (100%), Bovine (100%), Monkey (100%), Primate (100%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
FKBP15
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western Blot and immunoprecipitation. *The investigator should determine the optimal working dilution for a specific application.
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating macaque and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for FKBP15 Antibody
- FK506 binding protein 15, 133kDa
- FK506-binding protein 133kDa
- FK506-binding protein 15
- FKBP133
- FKBP-133
- FKBP-15,133 kDa FKBP
- PPP1R76,133 kDa FK506-binding protein
- regulatory subunit 76
- WAFL
Background
Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins.