Product: MM-103 (trifluoroacetate)
SAH3 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residues 50 and 100 of human adenosylhomocysteinase 3 (KIAA0828) using the numbering given in entry NP_056143.1 (GeneID 23382).
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| Localization |
Cytoplasm
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
AHCYL2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This SAH3 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, and Western Blot, where a band should be seen at ~70-80 kDa. In ICC/IF, cytoplasmic staining was observed in neuro-2a cells.
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for SAH3 Antibody
- adenosylhomocysteinase-like 2
- AdoHcyase 3
- ADOHCYASE3
- EC 3.3.1.1
- FLJ21719
- KIAA0828S-adenosylhomocysteine hydrolase-like 2
- putative adenosylhomocysteinase 3
- S-adenosylhomocysteine hydrolase-like protein 2
- S-adenosyl-L-homocysteine hydrolase 3
Background
In mammals, S-Adenosylhomocysteine hydrolase (SAH3 / AdoHcyase) catalyzes the hydrolysis of S-adenosylhomocysteine to form adenosine and homocysteine. AdoHcy is the product of all adenosylmethionine (AdoMet)-dependent biological transmethylations. These reactions have a wide range of products, and are common in all facets of biometabolism. As a product inhibitor, elevated levels of AdoHcy suppress AdoMet-dependent transmethylations. Thus, SAH3 is a regulator of biological transmethylation.