Recombinant Human TACI/TNFRSF13B/CVID Protein Summary
| Description |
A denatured recombinant protein with a His tag corresponding to amino acids 1 – 165 of TNFRSF13B.
Source: E.coli Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSGLGRS RRGGRSRVDQ EERFPQGLWT GVAMRSCPEE QYWDPLLGTC MSCKTICNHQ SQRTCAAFCR SLSCRKEQGK FYDHLLRDCI SCASICGQHP KQCAYFCENK LRSPVNLPPE LRRQRSGEVE NNSDNSGRYQ GLEHRGSEAS PALPGLKLSA DQVALVYS |
| Protein/Peptide Type |
Recombinant Protein
|
| Gene |
TNFRSF13B
|
| Purity |
>90%, by SDS-PAGE
|
Applications/Dilutions
| Theoretical MW |
20.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.4M urea
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
>90%, by SDS-PAGE
|
Alternate Names for Recombinant Human TACI/TNFRSF13B/CVID Protein
- CD267 antigen
- CD267
- CVID
- CVID2
- FLJ39942
- MGC133214
- TACI
- TACIMGC39952
- TNFRSF13B
- TNFRSF14B
- Transmembrane activator and CAML interactor
- tumor necrosis factor receptor 13B
- tumor necrosis factor receptor superfamily member 13B
- tumor necrosis factor receptor superfamily, member 13B
Background
TNFRSF13B, also known as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). It was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family. It controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. Recombinant human TNFRSF13B protein, fused to His-tag at N-terminus, was expressed in E.coli.