Calcitonin Antibody (14A2) Summary
| Immunogen |
Recombinant fragment (Human).
|
| Localization |
Secreted
|
| Specificity |
This cross-reacts with human calcitonin and procalcitonin.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CALCA
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Recommended pair for sandwich immunoassay (coating – conjugate): NB110-13042 (Coating) – NB120-11496 (Conjugate); NB100-73061 (Coating) – NB120-11496 (Conjugate)
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Calcitonin Antibody (14A2)
- ATP2B2plasma membrane calcium ATPase
- ATPase, Ca++ transporting, plasma membrane 4
- DKFZp686G08106
- DKFZp686M088
- EC 3.6.3
- EC 3.6.3.8
- Matrix-remodeling-associated protein 1
- matrix-remodelling associated 1
- MXRA1
- Plasma membrane calcium ATPase isoform 4
- Plasma membrane calcium pump isoform 4
- plasma membrane calcium pump
- plasma membrane calcium-transporting ATPase 4
- PMCA4b
- PMCA4PMCA4x
- sarcolemmal calcium pump
Background
Calcitonin is a 32 amino acid peptide hormone synthesized by the parafollicular cells of the thyroid. It causes a rapid, but short lived, reduction in serum calcium and phosphate by promoting the incorporation of those ions in the bones. This effect is opposite to that of parathyroid hormone. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.