gamma-Synuclein Antibody (1H10D2) Summary
| Immunogen |
Ni-NTA purified truncated recombinant gamma-Synuclein Antibody (1H10D2) expressed in E. Coli strain BL21 (DE3)
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| Specificity |
SNCG (1H10D2)
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SNCG
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites with PBS
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for gamma-Synuclein Antibody (1H10D2)
- BCSG1
- BCSG1PERSYN
- Breast cancer-specific gene 1 protein
- gamma-Synuclein
- persyn
- PRSN
- SNCG
- SRPRSN
- Synoretin
- synuclein, gamma (breast cancer-specific protein 1)
- Synuclein-gamma
Background
gamma-Synuclein Antibody (1H10D2)(also designated gamma-synuclein or breast cancer-specific protein 1),with 127-amino acid protein(about 14kDa), belongs to the synuclein family, which also includes alpha- and beta- synuclein.Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals,while gamma-Synuclein Antibody (1H10D2) is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of gamma-Synuclein Antibody (1H10D2) have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.