Desmin Antibody (10H7D2) Summary
| Immunogen |
Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3)
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| Specificity |
Desmin (10H7D2)
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
DES
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.03% Sodium Azide
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| Purity |
Protein A or G purified
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Alternate Names for Desmin Antibody (10H7D2)
- CMD1I
- CMD1IFLJ41013
- CSM1
- CSM2
- DES
- Desmin
- FLJ12025
- FLJ39719
- FLJ41793
- intermediate filament protein
Background
Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.