TORC1 Antibody (1B5) Summary
| Immunogen |
Purified recombinant fragment of human CRTC1 expressed in E. Coli.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CRTC1
|
| Purity |
Unpurified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for TORC1 Antibody (1B5)
- CREB regulated transcription coactivator 1
- CRTC1
- FLJ14027WAMTP1
- KIAA0616Transducer of regulated cAMP response element-binding protein 1
- MECT1
- MECT1CREB-regulated transcription coactivator 1
- mucoepidermoid carcinoma translocated 1
- Mucoepidermoid carcinoma translocated protein 1
- TORC1
- TORC1TORC-1
- Transducer of CREB protein 1
- transducer of regulated cAMP response element-binding protein (CREB) 1
- WAMTP1
Background
MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.