TLR2 Antibody (TL2.3) [PE] Summary
| Immunogen |
Human TLR2-expressing CHO cells
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
TLR2
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The antibody can be used for flow cytometry, immunohistology on frozen and paraffin sections, immunoprecipitation, Western blot and immuno assays. Furthermore the antibody is useful for neutralization of TLR2, it blocks TLR2 agonists induced cellular acti
|
| Agonist |
|
| Antagonist |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for TLR2 Antibody (TL2.3) [PE]
- CD282 antigen
- CD282
- TIL4CD282
- TLR2
- toll/interleukin 1 receptor-like 4
- Toll/interleukin-1 receptor-like protein 4
- toll-like receptor 2
Background
The TL2.1 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). To date, at least ten members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed by peripheral blood monocytes and is responsible for distinguishing different pathogens. TL2.1, a blocking antibody, has been used to study the role of TLR-2 as a pattern recognition receptor in microbial lipoprotein/lipopeptide induced cytokine production from human peripheral blood mononuclear cells. TL2.1 has been reported to immunoprecipitate human TLR2 (~90 kDa) from PBMC and HMEC.