TRF-1 Antibody (4E4) Summary
| Immunogen |
The exact sequence is proprietary.
|
| Localization |
Nuclear
|
| Marker |
Telomere Marker
|
| Specificity |
This antibody will recognize human TRF1.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
TERF1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2)
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for TRF-1 Antibody (4E4)
- NIMA-interacting protein 2
- PIN-2
- PIN2hTRF1-AS
- Telomeric protein Pin2/TRF1
- telomeric repeat binding factor (NIMA-interacting) 1
- telomeric repeat binding factor 1
- telomeric repeat binding protein 1
- telomeric repeat-binding factor 1
- TERF1
- TRBF1
- TRF1
- TRF-1
- TRF1FLJ41416
- TRFt-TRF1
- TTAGGG repeat-binding factor 1
Background
TRF1 binds the double-stranded telomeric repeat sequence, TTAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.