CD55/DAF Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human CD55. The exact sequence is proprietary.
|
| Localization |
Isoform 1: Membrane, Isoform 2: Cell membrane, GPI-anchor
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CD55
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for CD55/DAF Antibody
- CD55 antigen
- CD55 molecule, decay accelerating factor for complement (Cromer blood group)
- CD55
- CR
- CRdecay accelerating factor for complement (CD55, Cromer blood group system)
- CROMDAFcomplement decay-accelerating factor
- DAF
- decay accelerating factor for complement
- TC
Background
CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.