Product: Deoxycytidine triphosphate
LMAN1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human LMAN1. The exact sequence is proprietary.
|
| Localization |
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein; Golgi apparatus membrane; Single-pass membrane protein; Endoplasmic reticulum membrane
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
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| Host |
Rabbit
|
| Gene |
LMAN1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Chicken (81%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.82 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for LMAN1 Antibody
- ERGIC-53
- ERGIC53ER-Golgi intermediate compartment 53 kDa protein
- F5F8Dendoplasmic reticulum-golgi intermediate compartment protein 53
- FMFD1
- Gp58
- intracellular mannose specific lectin
- Intracellular mannose-specific lectin MR60
- Lectin mannose-binding 1
- lectin, mannose-binding, 1
- MCFD1coagulation factor V-factor VIII combined deficiency
- MR60
- protein ERGIC-53
Background
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq]