Product: Canertinib (dihydrochloride)
SIGIRR Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human SIGIRR. The exact sequence is proprietary.
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| Localization |
Membrane; Single-pass type III membrane protein
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
SIGIRR
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (86%), Rat (87%), Bovine (88%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for SIGIRR Antibody
- SIGIRR
- single Ig IL-1-related receptor
- Single Ig IL-1R-related molecule
- single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
- single immunoglobulin domain IL1R1 related
- Single immunoglobulin domain-containing IL1R-related protein
- TIR8
- TIR8MGC110992
- Toll/interleukin-1 receptor 8
Background
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.