TLR5 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human TLR5. The exact sequence is proprietary.
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| Localization |
Membrane, Single-pass type I membrane protein
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TLR5
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| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Agonist |
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Reactivity Notes
Expected cross reactivity based on sequence homology: Chimpanzee (100%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for TLR5 Antibody
- MGC126430
- MGC126431
- SLEB1FLJ10052
- TIL-3
- TIL3Toll/interleukin-1 receptor-like protein 3
- TLR5
- toll-like receptor 5
Background
The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adapter molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. Receptors for the C – C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.