Product: Y-33075 (dihydrochloride)
CDC45L Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human CDC45L. The exact sequence is proprietary.
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| Localization |
Cytoplasm, Nucleus
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CDC45
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CDC45L Antibody
- CDC45 cell division cycle 45-like (S. cerevisiae)
- cell division cycle 45 homolog (S. cerevisiae)
- cell division cycle 45-like 2
- human CDC45
- S.cerevisiae, homolog)-like
Background
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.