Kir6.2 Antibody Summary
| Immunogen |
Peptide with sequence ERRARFVSKKGNC corresponding to internal region (near N-Terminus) according to Uniprot Mouse NP_034732.1.
|
| Epitope |
ERRARFVSKKGNC
|
| Clonality |
Polyclonal
|
| Host |
Goat
|
| Gene |
KCNJ11
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
WB: Approx. 45 kDa band observed in human skeletal muscle lysates (calculated MW of 43.6 kDa band according to NP_034732.1). IHC-P: Human pancreas shows variable staining across the islet of langerhans.
|
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Kir6.2 Antibody
- ATP-sensitive inward rectifier potassium channel 11
- beta-cell inward rectifier subunit
- BIRKIR6.2
- HHF2
- IKATP
- Inward rectifier K(+) channel Kir6.2
- inwardly rectifying potassium channel KIR6.2
- Kir6.2
- MGC133230
- PHHI
- potassium channel inwardly rectifing subfamily J member 11
- Potassium channel, inwardly rectifying subfamily J member 11
- potassium inwardly-rectifying channel, subfamily J, member 11
- TNDM3
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq]