PXR/NR1I2 Antibody Summary
| Immunogen |
NR1I2 (NP_003880.3, 1 a.a. – 434 a.a.) full-length human protein. MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
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| Clonality |
Polyclonal
|
| Host |
Mouse
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| Gene |
NR1I2
|
| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
It has been used for IF and WB.
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
|
Notes
Quality control test: Antibody reactive against mammalian transfected lysate.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for PXR/NR1I2 Antibody
- BXR
- NR1I2
- nuclear receptor subfamily 1 group I member 2
- nuclear receptor subfamily 1, group I, member 2
- ONR1
- Orphan nuclear receptor PAR1
- Orphan nuclear receptor PXR
- PAR
- PAR1
- PAR2
- Pregnane X receptor
- PRR
- PXR
- PXRPARq
- SAR
- Steroid and xenobiotic receptor
- SXR
- SXRBXR
Background
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq]