PAK3 Antibody (1H7) Summary
| Immunogen |
PAK3 (NP_002569, 1 a.a. – 90 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGE
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| Specificity |
PAK3 (1H7)
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| Isotype |
IgG2a Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
PAK3
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF and ELISA.
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| Publications |
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for PAK3 Antibody (1H7)
- beta-PAK
- bPAK
- CDKN1A
- EC 2.7.11
- EC 2.7.11.1
- hPAK3
- mental retardation, X-linked 47
- MRX30
- MRX47
- oligophrenin-3
- OPHN3
- p21 (CDKN1A)-activated kinase 3
- p21 protein (Cdc42/Rac)-activated kinase 3
- p21-activated kinase 3
- PAK3
- PAK-3
- PAK3beta
- serine/threonine-protein kinase PAK 3
Background
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.