NMDA receptor C1 Antibody Summary
| Immunogen |
Peptide from the NR1 subunit, C1 splice variant insert of the NMDA receptor.
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| Specificity |
Specific for the ~120k NR1 subunit of the NMDA receptor containing the C1 splice variant insert. Does not recognize the NR1 subunits of the NMDA receptor that do not contain the C1 insert.
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| Predicted Species |
Canine (100%), Bovine (100%), Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
NB 300-115 can be used in Western blot where a band is seen at ~ 100 kDa representing the NMDAR1 C1 splice variant.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Theoretical MW |
105 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
It is anticipated that the antibody will also work with bovine, canine, and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
No buffer
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
Immunogen affinity purified
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| Reconstitution Instructions |
Reconstitute with 50 ul PBS to desired concetration.
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Background
The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.