Product: Alvespimycin (hydrochloride)
NMDAR2C Splice Variant Antibody Summary
| Immunogen |
Peptide from the NR1 subunit, C2 splice variant insert of rat NMDA receptor.
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| Specificity |
Specific for the ~120k NR1 subunit of the NMDA Receptor containing the C2 splice variant insert. Does not recognize the NR1 subunits of the NMDA receptor that do not contain the C2 insert.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GRIN2C
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
By Western blot a band is seen at ~120 kDa representing the NMDAR1 C2 splice variant.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Theoretical MW |
106 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
Tested in Mouse and Rat. Predicted cross-reactivity based on sequence identity: Human (100%).
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
No buffer
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
Immunogen affinity purified
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| Reconstitution Instructions |
Reconstitute with 50 ul PBS to desired concetration.
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Alternate Names for NMDAR2C Splice Variant Antibody
- glutamate [NMDA] receptor subunit epsilon-3
- glutamate receptor, ionotropic, N-methyl D-aspartate 2C
- NMDAR2CNR2C
- N-methyl D-aspartate receptor subtype 2C
- N-methyl-D-aspartate receptor subunit 2C
Background
The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.