IFN-alpha/beta R1 [p Ser535, p Ser539] Antibody Summary
| Immunogen |
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer535,539 of human interferon-alpha receptor, type I, subunit I (IFNAR1).
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| Modification |
p Ser535, p Ser539
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| Localization |
Type I membrane protein.
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| Specificity |
Specific for IFNAR1 protein phosphorylated at Ser535,539.
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| Predicted Species |
Human (100%), Mouse (100%), Bovine (100%), Primate (100%), Sheep (100%), Canine (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
IFNAR1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Note: the molecular weight of the IFNNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells; the mature form is ~110 – 130 kDa.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Alternate Names for IFN-alpha/beta R1 [p Ser535, p Ser539] Antibody
- alpha-type antiviral protein
- AVP
- beta-type antiviral protein
- CRF2-1
- Cytokine receptor class-II member 1
- Cytokine receptor family 2 member 1
- human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
- IFN-alpha/beta R1
- IFN-alpha/beta receptor 1
- IFN-alpha-REC
- IFNAR
- IFNAR1
- IFN-aR1
- IFNBR
- IFNbR1
- IFN-bR1
- IFN-R-1
- interferon (alpha, beta and omega) receptor 1
- interferon alpha/beta receptor 1
- interferon-alpha/beta receptor alpha chain
- interferon-beta receptor 1
- Type I interferon receptor 1
Background
Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon Receptor(IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.