Insulin Antibody (IRDN/805) – Azide and BSA Free Summary
| Immunogen |
Recombinant INS protein
|
| Localization |
Cytoplasmic
|
| Marker |
beta-Cell & Insulinoma Marker
|
| Specificity |
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
INS
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Hu-chromosome location: 11p15.5 Immunohistochemistry-Paraffin 0.5 – 1 ug/ml for 30 minutes at RT; No special pretreatment is required for staining of formalin/paraffin tissues. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
No Preservative
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for Insulin Antibody (IRDN/805) – Azide and BSA Free
- IDDM2
- ILPR
- INS
- Insulin
- IRDN
- MODY10
- proinsulin