Insulin Antibody (IRDN/805)

Product: Clopidogrel

Insulin Antibody (IRDN/805) Summary

Immunogen
Recombinant INS protein
Localization
Cytoplasmic
Marker
beta-Cell & Insulinoma Marker
Specificity
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
INS
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5 – 1 ug/million cells in 0.1 ml
  • Immunohistochemistry-Paraffin 0.5 – 1.0 ug/ml
  • Immunofluorescence 1 – 2 ug/ml
Application Notes
Hu-chromosome location: 11p15.5
Immunohistochemistry-Paraffin 0.5 – 1 ug/ml for 30 minutes at RT; No special pretreatment is required for staining of formalin/paraffin tissues. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Insulin Antibody (IRDN/805)

  • IDDM2
  • ILPR
  • INS
  • Insulin
  • IRDN
  • MODY10
  • proinsulin

PMID: 11278295