Chromogranin A Antibody (CHGA/765) Summary
| Immunogen |
Recombinant human chromogranin A protein
|
| Localization |
Finely granular cytoplasmic
|
| Marker |
Neuroendocrine Marker
|
| Specificity |
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CHGA
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Hu-chromosome location: 14q32.12
Molecular weight of antigen: 68-75kDa Immunohistochemistry-Paraffin 0.5 – 1 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 – 20 min followed by cooling at RT for 20 minutes. |
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for Chromogranin A Antibody (CHGA/765)
- betagranin (N-terminal fragment of chromogranin A)
- Betagranin
- Catestatin
- CGA
- CHGA
- Chromofungin
- chromogranin A (parathyroid secretory protein 1)
- Chromogranin A
- chromogranin-A
- Pancreastatin
- Parastatin
- Parathyroid Secretory Protein 1
- Pituitary Secretory Protein I
- SP-I