IL-1 beta/IL-1F2 Antibody Summary
| Description |
This is an IgG preparation of whole rabbit serum purified by DEAE fractionation.
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| Immunogen |
This antibody was prepared by repeated immunizations with recombinant human IL-1 beta produced in E.coli. The MW of the recombinant 153 aa IL-1 beta was 17 kDa with the N-terminal amino acid at position alanine 117. This cleavage site is generated by the IL-1 beta converting enzyme (ICE, capase-1).
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| Specificity |
This antibody is primarily directed against mature, 17,000 MW human IL-1 beta.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
IL1B
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| Purity |
Ion exchange chromatography
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Anti-Human IL-1 beta has been tested for use in neutralizations, ELISA, radioimmunoassays, flow cytometry, immunohistochemistry, immunoblotting and immunoprecipitation. It recognizes the 17 kDa mature IL-1 beta.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
Ion exchange chromatography
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| Reconstitution Instructions |
Reconstitute with 0.1 ml distilled water.
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Alternate Names for IL-1 beta/IL-1F2 Antibody
- catabolin
- IL1 beta
- IL-1 beta
- IL-1
- IL1B
- IL-1b
- IL1-BETA
- IL-1F2
- IL1F2IL-1 beta
- interleukin 1, beta
- interleukin-1 beta
- preinterleukin 1 beta
- pro-interleukin-1-beta
Background
IL-1 beta (also known as Interleukin-1 beta, IL-1 beta and catabolin) is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 beta is a monomeric secreted protein that may be released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.