FKBP38 Antibody Summary
| Immunogen |
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human FKBP8 protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
FKBP8
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This protein A purified antibody has been tested for use in ELISA and western blotting. Expect a band approximately 64 kDa in size corresponding – FKBP8 by western blotting in the appropriate cell lysate or extract.
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse (93%), Rat (93%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
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| Preservative |
0.01% Sodium Azide
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| Purity |
Protein A purified
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Alternate Names for FKBP38 Antibody
- 38 kDa FK506-binding protein
- EC 5.2.1.8,38 kDa FKBP
- FK506 binding protein 8, 38kDa
- FK506-binding protein 8 (38kD)
- FK506-binding protein 8
- FKBP38
- FKBP-38
- FKBP38PPIase FKBP8
- FKBP8
- FKBP-8
- FKBPr38
- hFKBP38
- peptidyl-prolyl cis-trans isomerase FKBP8
- rotamase
Background
FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.