Mucin 5AC Antibody (1-13M1) Summary
| Immunogen |
M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient.
|
| Localization |
Cytoplasmic
|
| Specificity |
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC).Its epitope is located in the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. MAb 1-13M1 pairs with MAb 9-13M1 to measure MUC5AC protein by ELISA. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MUC5AC
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Hu-chromosome location: 11p15.5
Molecular weight of antigen: >1,000kDa Immunohistochemistry-Frozen 0.5 – 1 ug/ml for 30 minutes at RT |
Reactivity Notes
Human, Monkey, Rabbit, Cat, Mouse, Rat, Cow, Chicken. Does not react with pig, hedgehog. Others-not known.
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for Mucin 5AC Antibody (1-13M1)
- gastric mucin
- leB
- lewis B blood group antigen
- major airway glycoprotein
- MUC5
- mucin 5, subtypes A and C, tracheobronchial/gastric
- mucin 5AC, oligomeric mucus/gel-forming pseudogene
- mucin 5AC, oligomeric mucus/gel-forming
- mucin-5 subtype AC, tracheobronchial
- mucin-5AC
- TBM
- tracheobronchial mucin