Product: DL-threo-2-methylisocitrate
CRMP2 Antibody (33CT11.40.3) Summary
| Immunogen |
KLH-conjugated synthetic peptide between amino acids 463-492 from human DRP-2.
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| Predicted Species |
Rat (90%), Chicken (90%), Bovine (90%). Backed by our 100% Guarantee.
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| Isotype |
IgG2b
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
DPYSL2
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| Purity |
Unpurified
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| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
Ascites
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| Preservative |
0.9% Sodium Azide
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| Purity |
Unpurified
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Alternate Names for CRMP2 Antibody (33CT11.40.3)
- Collapsin response mediator protein 2
- CRMP-2
- CRMP2N2A3
- DHPRP2
- dihydropyrimidinase-like 2 long form
- dihydropyrimidinase-like 2
- dihydropyrimidinase-related protein 2
- DRP2collapsin response mediator protein hCRMP-2
- DRP-2ULIP-2
- ULIP2
- Unc-33-like phosphoprotein 2
Background
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimers disease.